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New research paves the way for a new schizophrenia treatment, by testing the effect of CBD oil on rats. The study suggests that the hemp-derived substance may improve schizophrenia-specific cognitive impairment, without any of the side effects generated by current medication.

Schizophrenia affects about 1.1 percent of the American population – or approximately 3.5 million adults. The symptoms are wide-ranging and vary between patients. These include so-called positive symptoms – that is, symptoms that do not appear in healthy individuals – negative symptoms, called negative because they are a disruption to normal behavior, and finally, cognitive symptoms.

Behavior displayed by sufferers of cognitive symptoms includes difficulty paying attention or concentrating, trouble making decisions, as well as problems with comprehending and using new information. While currently available medication effectively treats positive symptoms – such as hallucinations and delusions – it is less effective in treating cognitive symptoms and negative symptoms, such as reduced speaking, reduced social interaction, and blunted feelings.

For some patients, antipsychotic drugs can cause side effects, including muscle spasms, restlessness, tremors, as well as drowsiness, or dizziness. Other prescribed medication can lead to weight gain, metabolic changes, an increased risk of diabetes, and high cholesterol levels. This is why new research has looked at the potential of CBD oil for treating some of the symptoms of schizophrenia.

CBD can affect learning, memory, and attention, which suggests that the compound could help manage cognitive symptoms more effectively and with fewer side effects than medication currently available.

The researchers – led by Dr. Katrina Green from the University of Wollongong, Australia – first discovered the therapeutic value of CBD oil when they previously conducted a review of 27 studies.

“From this review, we found that CBD will not improve learning and memory in healthy brains, but may improve aspects of learning and memory in illnesses associated with cognitive impairment, including Alzheimer’s disease, as well as neurological and neuro-inflammatory disorders,” explains Dr. Green.

“Evidence suggests that CBD is neuroprotective and can reduce cognitive impairment associated with use of delta-9-tetrahydrocannabinol (THC), the main psychoactive component of cannabis,” Dr. Green adds.

Based on this evidence, Ph.D. candidate Ashleigh Osborne, together with Dr. Green – who is her supervisor – set out to examine if CBD can reduce cognitive impairment in rodents.

The team – made up of Osborne, Dr. Green, senior professor Xu-Feng Huang, and Ph.D. candidate Ilijana Babic – used a prenatal infection model to investigate the effect of chronic CBD treatment on cognition and social interaction. First, they infected the pregnant rats in the 15th day of gestation with polyinosinic-polycytidilic acid – a compound commonly used to generate psychiatric disorders such as schizophrenia and autism in rats.

Then, they injected the male rats offspring with 10 milligrams per kilogram of CBD for 3 weeks. Dr. Green and her team measured the body weight, food, and water intake of the offspring every week. They tested the rats’ cognition and working memory using rewarded alternation in T-maze tests and the Novel Object Recognition test. Additionally, they tested sociability using a social interaction test.

“We found that CBD was able to restore recognition and working memory, as well as social behavior to normal levels. These findings are interesting because they suggest that CBD may be able to treat some of the symptoms of schizophrenia that are seemingly resistant to existing medications. In addition, CBD treatment did not alter body weight or food intake, which are common side effects of antipsychotic drug treatment.“

The researchers caution against the use of both recreational and medical marijuana derived products for the treatment of schizophrenia however,, as the THC in these products can intensify schizophrenic symptoms. Although the results were encouraging, the scientists noted that further testing is required to discover if CBD oil has the same therapeutic effect in people.

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Cannabidiol, or CBD, is one of over 60 compounds called cannabinoids. Cannabinoids are found in many plants but are most commonly linked to marijuana. Unlike some cannabinoids such as tetrahydrocannabinol (THC), CBD does not produce a “high” or psychoactive effect. This is because CBD does not affect the same receptors as THC.

The human body has an endocannabinoid system (ECS) that receives and translates signals it receives from cannabinoids in the body. The body produces some cannabinoids on its own, which are called endocannabinoids. The ECS helps regulate functions such as sleep, immune-system responses, and pain.

THC produces a “high” feeling by affecting the brain’s endocannabinoid receptors. This activates the brain’s reward system, producing pleasure chemicals such as dopamine. CBD is an entirely different compound, and its effects are very complex. It is not psychoactive, meaning it does not produce a “high” or change a person’s state of mind. Instead, it influences the body to use its own endocannabinoids more effectively.

According to one study posted to Neurotherapeutics, this is because CBD itself does very little to the ECS. Instead, it activates or inhibits other compounds in the endocannabinoid system. An example of this is CBD stops the body from absorbing anandamide, one compound associated with regulating pain. Increased levels of anandamide in the bloodstream may reduce the amount of pain a person is feeling.

CBD may also limit inflammation in the brain and nervous system, which may help to reduce pain, insomnia, and certain immune-system responses.

CBD oil has been used for thousands of years to treat various types of pain, but only recently have studied been undertaken by the medical community to determine its medical benefits. The purest form of CBD oil is usually refined from industrial hemp plants, not only do they contain a higher CBD content than recreational and medical marijuana, but it is almost devoid of THC, allowing users to perform their daily tasks without the euphoric, high sensations often associated with using marijuana products.

Many of the compounds found in natural hemp or marijuana can vary in strength. Often CBD levels can vary depending on the plants breeding, environment and overall quality. Most CBD oil comes from industrial hemp, which usually contains a higher CBD content than either recreational or medicinal marijuana.

Manufactures of CBD oil use different methods to extract the compound which is then added to a carrier oil and called CBD oil. Available in different strengths, it can be used in various ways such as simple ingestion of the drops, diluting the CBD into a hot drink, or mixed with food and eaten.

Arthritis

A study in the European Journal of Pain used an animal model to see if CBD could help reduce the pain and suffering caused by arthritis. Researchers applied a gel containing CBD oil to rats with arthritis for 4 days. Their research noted a significant drop in inflammation and signs of pain, without additional side effects. Many people using CBD oil for arthritis have found relief from their pain, but more human studies need to be conducted to confirm these findings.

Multiple Sclerosis

Multiple sclerosis (MS) is an autoimmune disease that affects the entire body through the nerves and brain. Muscle spasms are one of the most common symptoms of MS. These spasms can be so severe, they can cause some people to be in constant pain.

One report found that short-term use of CBD oil could reduce the levels of spasticity and pain a person feels. The results are modest, but many people reported a reduction in MS symptoms, however, more human studies are needed to verify these results.

Chronic Pain

The same report studied CBD for reducing general chronic pain. Researchers compiled the results of multiple systematic reviews covering dozens of trials and studies. Their research concluded that there is substantial evidence that CBD oil is an effective treatment for chronic pain in adults.

A separate study in the Journal of Experimental Medicine supports these results. The research suggested that both pain and inflammation could be reduced through the use of CBD oil. The report also concluded that subjects were unlikely to build up a tolerance to  CBD oil, so avoiding the need to continually increase their dosage. Researchers concluded that cannabinoids such as CBD could be a helpful new treatment for people with chronic pain.

We offer some of the finest CBD oil for sale online. Produced by I Love Growing Marijuana, one of the world’s leading suppliers of marijuana seeds and products, this 5%, 10 ml bottle contains an average of 200 drops of 12 mg of CBD oil, and is made from clean, industrial hemp with an extremely low THC content, suitable for all ages and both day and night use.

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